Browsing by Author "Chazin, Walter J"
Now showing items 1-4 of 4
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Cordoba, John James; 0000-0001-5400-163X (2023-10-27)Department: Biomedical SciencesDNA replication in eukaryotes relies on the synthesis of a ~30-nucleotide chimeric RNA/DNA primer strand through the dual action of the heterotetrameric polymerase α-primase (pol-prim) enzyme. Synthesis of an initial ...
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Salay, Lauren Elizabeth; 0000-0001-8513-1891 (2020-11-20)Department: Chemical & Physical BiologyFaithful duplication of DNA lies at the center of DNA replication, defects in which can lead to cancer and other diseases of genomic instability. Generating copies of the two stands of the DNA duplex begins with synthesis ...
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Krishnamoorthy, Archana; 0000-0002-3305-6612 (2022-01-13)Department: BiochemistryDNA replication is frequently challenged by obstacles that require accurate and timely repair to maintain genome stability. In some cases, repair mechanisms are coupled with the replisome to process the damaged DNA. One ...
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Structural and Biophysical Investigation of Calmodulin Binding to the Third Domain of Human Prp40A Ferrer, Brian James; 0000-0003-0500-146X (2022-06-15)Department: Chemical & Physical BiologyHuman Pre-mRNA-processing factor 40 homolog A (hPrp40A) is a splicing factor that interacts with the Huntington’s Disease (HD) protein huntingtin (HTT). Evidence has accumulated that both HTT and hPrp40A are modulated by ...