Browsing by Author "Charles R. Sanders, Ph.D."
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Effects of DNA Geometry and Topoisomerase II Poisons on Human and Bacterial Type II Topoisomerases Ashley, Rachel Erin (2017-03-15)Department: BiochemistryThe topological state of DNA has a dramatic effect on nucleic acid processes in cells. Type II topoisomerases are necessary enzymes that help regulate the topological state of the genome, but their activity requires the ...
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Keithly, Mary Elizabeth (2016-07-08)Department: ChemistryStructure, substrate selectivity, and catalytic mechanism of the fosfomycin resistance enzyme, FosB, from Gram-positive pathogens By: Mary E. Keithly Fosfomycin, a broad spectrum antibiotic, is used clinically to treat ...