Browsing by Author "Capra, John A."

Now showing items 1-5 of 5

    • Fungal genome evolution and software for the life sciences 
      Steenwyk, Jacob Lucas; 0000-0002-8436-595X (2022-03-29)
      Department: Biological Sciences
      Deep genome sequencing of the fungal kingdom, an ancient and diverse eukaryotic lineage, has shed light on the dynamics of genome evolution. For example, these studies have underscored the importance of evolution by gene ...
    • IgG4-related disease: Association with a rare gene variant expressed in cytotoxic T cells 
      Newman, John H.; Shaver, Aaron; Sheehan, Jonathan H.; Mallal, Simon; Bastarache, Lisa; Riebau, Derek; Pilkinton, Mark; Smith, Scott A.; McDonnell, Wyatt J.; Capra, John A.; Meiler, Jens; Cogan, Joy; Hamid, Rizwan; Phillips, John A., III (Molecular Genetrics & Genome Medicine, 2019-06)
      BackgroundFamily screening of a 48-year-old male with recently diagnosed IgG4-related disease (IgG4-RD) revealed unanticipated elevations in plasma IgG4 in his two healthy teenaged sons. MethodsWe performed gene sequencing, ...
    • Signatures of Recent Positive Selection in Enhancers Across 41 Human Tissues 
      Moon, Jiyun M.; Capra, John A.; Abbot, Patrick; Rokas, Antonis (G3-GENES Genomes Genetics, 2019-08)
      Evolutionary changes in enhancers are widely associated with variation in human traits and diseases. However, studies comprehensively quantifying levels of selection on enhancers at multiple evolutionary periods during ...
    • The contribution of the 3D genome to gene regulation, human evolution, and disease 
      McArthur, Evonne; 0000-0003-4566-4321 (2022-03-21)
      Department: Human Genetics
      Interpreting the consequences of the millions of genetic variants present in each human genome requires an understanding of human evolutionary history coupled with mechanistic knowledge of genome function. Given the emerging ...
    • The role of ancient genetic variation on human adaptation: Insights from trans-species and introgressed variation 
      Velazquez-Arcelay, Keila S.; 0000-0001-7937-7182 (2023-11-15)
      Department: Biological Sciences
      Due to human demographic history and the action of natural selection, most genetic variation in present-day humans is of recent origin. However, a smaller number of variants have persisted over hundreds of thousands of ...