Browsing by Author "Capra, John A"

Now showing items 1-3 of 3

    • Dissecting the evolution of human enhancer sequences 
      Fong, Sarah; 0000-0003-0900-5505 (2022-11-03)
      Department: Human Genetics
      Divergent regulation of gene expression is a major driver of species divergence, however, the relationship between gene regulatory sequence evolution and its functional effects on gene expression are poorly understood. ...
    • Identification, Interpretation, and Evolution of Gene Regulatory Enhancer Landscapes 
      Benton, Mary Lauren; 0000-0002-5485-1041 (2020-08-18)
      Department: Biomedical Informatics
      The improper regulation of gene expression is a main cause of complex disease. Non-coding single nucleotide variants influence disease risk by altering gene regulatory elements, such as promoters and enhancers. In addition ...
    • Predicting gene regulatory changes across human evolution using ancient DNA 
      Colbran, Laura Legendre; 0000-0002-7752-6671 (2020-07-24)
      Department: Human Genetics
      Sequencing DNA derived from ancient bones (‘aDNA’) enabled direct genetic comparison of anatomically modern humans (AMHs) and their ancestral populations, as well as archaic hominins like Neanderthals and Denisovans. From ...