Browsing by Author "BethAnn McLaughlin"
Now showing items 1-7 of 7
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Helmcke, Kirsten Jeanne (2010-01-18)Department: PharmacologyMethylmercury (MeHg), a known neurotoxicant, is found in seafood, leading to regular exposure of humans to this compound. Many of the molecular targets and detoxifying components of MeHg toxicity, including glutathione ...
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Mazalouskas, Matthew David (2014-04-14)Department: PharmacologyThe macromolecular assembly of protein serine/threonine phosphatase•kinase complexes mechanistically enhances the speed and fidelity of cell signaling events. These signaling modules allow for acute regulation of substrates ...
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Federspiel, Joel Davis (2016-04-06)Department: BiochemistryApoptosis signal-regulating kinase 1 (ASK1) is a critical sensor of cellular stress that is capable of integrating several chemically distinct signals into a single response pathway and is believed to play a role in several ...
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Watchmaker, Jennifer Morgan (2017-09-25)Department: Chemical and Physical BiologyCerebrovascular disease (CVD) encompasses conditions that affect the blood supply to the brain. CVD results in hemodynamic impairment, and when the brain can no longer compensate for decreased oxygen delivery to tissue, ...
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Novel Functions of C-terminus of HSC70-Interacting Protein (CHIP) in Mitophagy and Neuroprotection Lizama, Britney Nola (2018-07-27)Department: NeuroscienceC-terminus of HSC70-interacting protein (CHIP, STUB1) is a ubiquitously expressed cytosolic E3-ubiquitin ligase. CHIP-deficient mice exhibit cardiovascular stress and motor dysfunction prior to premature death. This phenotype ...
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Nordquist, Kyle Andrew (2011-08-31)Department: BiochemistryUbiquitination is a post-translational modification, that functions in a variety of cellular signaling pathways. Unlike modification with a small functional group by a single enzyme, modification by the small protein ...
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Palubinsky, Amy Marie (2019-06-17)Department: NeuroscienceNeuronal protein refolding and degradation in response to stress is largely mediated by the HSP70 chaperone complex and is critical for maintaining cell function and survival. While some components of the triage machinery ...