Browsing by Author "Barnett, Joey"

Now showing items 1-9 of 9

    • Exploring the APOE-specific effects of VEGF family expression and signaling in cognitive aging and Alzheimer's disease 
      Moore, Annah; 0000-0002-4433-6134 (2020-06-14)
      Department: Pharmacology
      No current pharmacologic treatments stop the progression of Alzheimer’s disease (AD), the most common major neurocognitive disorder. High levels of cerebrospinal fluid (CSF) vascular endothelial growth factor (VEGFA) are ...
    • Investigating a role for Protein Kinase D1 (PRKD1) in adipose tissue browning 
      Crowder, Mark Kamau Alexander; 0000-0003-3675-9169 (2023-06-05)
      Department: Pharmacology
      Brown adipose tissue (BAT) has in recent times been rediscovered in adult humans, and together with work from preclinical models, shown to have the potential of providing a variety of positive metabolic benefits. These ...
    • Targeting Lipid Dicarbonyls to Prevent Inflammation-mediated Atrial Fibrillation 
      Murphy, Matthew Benton; 0000-0002-2297-2703 (2023-06-05)
      Department: Pharmacology
      Inflammation and oxidative stress are linked to the pathogenesis of atrial fibrillation (AF). Reactive dicarbonyls generated by lipid peroxidation represent a major component of oxidative injury, but their role in ...
    • Targeting Lipid Dicarbonyls to Prevent Inflammation-mediated Atrial Fibrillation 
      Murphy, Matthew Benton; 0000-0002-2297-2703 (2023-06-05)
      Department: Pharmacology
      Inflammation and oxidative stress are linked to the pathogenesis of atrial fibrillation (AF). Reactive dicarbonyls generated by lipid peroxidation represent a major component of oxidative injury, but their role in ...
    • TREM2 Associations with Concomitant Pathology in Alzheimer’s Disease 
      Winfree, Rebecca Lynn; 0000-0001-9798-2589 (2022-08-17)
      Department: Pharmacology
      Differential expression of both Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) and its soluble fragment have been linked to Alzheimer’s disease (AD) risk in animal models and humans. The TREM2 pathway represents ...
    • Using multi-omic approaches to identify modulators of Alzheimer’s disease risk 
      Seto, Mabel; 0000-0001-8567-2532 (2022-03-25)
      Department: Pharmacology
      Alzheimer's disease (AD) is a neurodegenerative disorder that is characterized by neurodegeneration, memory loss and cognitive impairment. Sporadic late-onset AD is the most common form of the disease; it makes up approximately ...
    • Wnt receptor regulation by the tumor suppressor APC 
      Bryant, Jamal Michael; 0000-0002-8232-1478 (2024-03-22)
      Department: Pharmacology
      The canonical Wnt signaling pathway is a master regulator of metazoan development and disease. The tumor suppressor APC negatively regulates Wnt pathway activation, and is conventionally thought to function primarily in ...
    • Wnt receptor regulation by the tumor suppressor APC 
      Bryant, Jamal Michael; 0000-0002-8232-1478 (2024-03-22)
      Department: Pharmacology
      The canonical Wnt signaling pathway is a master regulator of metazoan development and disease. The tumor suppressor APC negatively regulates Wnt pathway activation, and is conventionally thought to function primarily in ...
    • Wnt receptor regulation by the tumor suppressor APC 
      Bryant, Jamal Michael; 0000-0002-8232-1478 (2024-03-22)
      Department: Pharmacology
      The canonical Wnt signaling pathway is a master regulator of metazoan development and disease. The tumor suppressor APC negatively regulates Wnt pathway activation, and is conventionally thought to function primarily in ...