Browsing by Author "Anne Kenworthy"
Now showing items 1-20 of 25
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Shi, Jian (2008-01-17)Department: Molecular Physiology and BiophysicsSmall heat shock proteins (sHSPs) are a ubiquitous family of chaperones that protect unfolded proteins from irreversible aggregation in the cell. Human sHSPs are associated with the pathology of a variety of diseases. The ...
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Beachboard, Dia Chenelle (2015-02-11)Department: Microbiology and ImmunologyCoronaviruses are positive-sense RNA viruses that cause significant diseases in humans. Severe Acute Respiratory Syndrome coronavirus (SARS-CoV) caused a pandemic in 2002-2003, and Middle East Respiratory Syndrome coronavirus ...
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Thiel, Kristina Wyatt (2007-10-03)Department: BiochemistryThe ErbB family of receptor tyrosine kinases regulates cell growth, differentiation, and tumorigenesis. This dissertation contains two independent studies of ErbB-1 and ErbB-4. In one study, the intracellular juxtamembrane ...
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Brown, Abigail Maureen (2007-07-31)Department: Molecular Physiology and BiophysicsMOLECULAR PHYSIOLOGY AND BIOPHYSICS DOPAMINE DEPLETION ALTERS THE BALANCE BETWEEN CA2+/CALMODULIN-DEPENDENT PROTEIN KINASE II AND PROTEIN PHOSPHATASE I ABIGAIL M. BROWN Dissertation under the direction of Professor ...
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Caldwell, Brittany Catherine (2016-04-04)Department: Biomedical EngineeringInsulin resistance together with insufficient insulin secretion leads to the development of type II diabetes mellitus. Glucose-stimulation of insulin secretion has been extensively studied, but other pathways that regulate ...
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Ustione, Alessandro (2012-12-11)Department: Molecular Physiology and BiophysicsInsulin secretion is the natural response to hyperglycemia, and it is crucial to maintain glucose homeostasis in healthy individuals. Impairment in this regulation eventually results in Type-2 diabetes. From the perspective ...
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Cox, Brian Elbert (2007-09-20)Department: PathologyThis project is concerned with the lysosomal accumulation of lipid in the developing macrophage foam cell as occurs in the atherosclerotic lesion. Lysosomal lipid accumulation in atherosclerosis is a feature of advanced ...
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Braun, Nicole Ann (2011-05-03)Department: PathologyInvariant natural killer T (iNKT) cells are a specialized subset of immune regulatory cells that recognize glycolipid antigens and are thought to be pro-atherogenic under hyperlipidemic conditions. We previously reported ...
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Moore, Timothy Craig (2018-01-11)Department: Chemical EngineeringSkin plays the vital role in human physiology of providing a barrier from the external environment. This barrier function is localized to the lipid matrix of the outermost layer, the stratum corneum. While much has been ...
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Mangione, MariaSanta (2019-09-13)Department: Cell and Developmental BiologyCytokinesis is the physical separation of two daughter cells. Coordination of cytokinesis with genome duplication and segregation is essential for the viability of all cells. Yeast, amoebas, and animal cells assemble an ...
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Zamora Vargas, Paula Francisca (2018-07-10)Department: Microbiology and ImmunologyViral nonstructural proteins, which are not packaged into virions, are essential for the replication of most viruses. Reovirus, a nonenveloped, double-stranded RNA (dsRNA) virus, encodes three nonstructural proteins that ...
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Le Marchand, Sylvain (2011-02-22)Department: Molecular Physiology and BiophysicsUnder hypoglycemic conditions, glucagon is secreted from α-cells, within pancreatic islets of Langerhans, to stimulate hepatic glucose output and, therefore, to restore proper glycemia. Once normoglycemia is reestablished, ...
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McDonald, Nathan Andrew (2017-07-13)Department: Cell and Developmental BiologyCytokinesis is the final step in the cell cycle where one cell is physically divided into two. Animal and fungal cells perform cytokinesis with an actin- and myosin-based molecular machine, the contractile ring. A complete ...
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Klaus, Colin James Stockdale (2017-08-28)Department: MathematicsTwo projects in classical analysis and two projects in computational mathematics applied to biology are considered. First a necessary and sufficient condition for the continuity at a point of minima for parabolic variational ...
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Melville, David Boyd (2012-05-08)Department: Cell and Developmental BiologyThe COPII machinery is the primary mediator of ER-to-Golgi transport and mutations in different COPII (Coat Protein II complex) paralogs are associated with diverse human diseases. Each tissue has vastly different requirements ...
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Jodoin, Jeanne Nicole (2013-12-10)Department: Cell and Developmental BiologyCytoplasmic dynein is a large, multimeric complex that walks along microtubules to perform multiple functions within the cell. This motor is commonly found associated with the dynein-activating complex, dynactin. Dynein ...
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Garbarini, Nicole Jodela (2008-04-28)Department: NeuroscienceThe neuron-specific electroneutral potassium (K+) and chloride (Cl-) cotransporter, KCC2, is a key regulator of neuronal Cl-. KCC2 has been shown to play a critical role in controlling neuronal excitability, yet little ...
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Ding, Jinlong (2014-12-01)Department: Molecular Physiology and BiophysicsHereditary motor and sensory neuropathy associated with agenesis of the corpus callosum (HMSN/ACC or ACCPN) is an autosomal recessive disease caused by the disruption of the SLC12A6 gene, which encodes the K–Cl cotransporter-3 ...
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Prewitt, Allison Renee (2015-07-07)Department: Cell and Developmental BiologyHeritable Pulmonary Arterial Hypertension (HPAH) is a rare, fatal disease of the pulmonary vasculature for which there is no cure. The majority of HPAH patients inherit mutations in the BMP type 2-receptor gene, BMPR2, but ...
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Barrett, Paul John (2013-09-23)Department: BiochemistryBiochemistry Structural and Cholesterol Binding Properties of the Amyloid Precursor Protein C-Terminal Fragment C99 and the Etiology of Alzheimer’s Disease Paul John Barrett Dissertation under the direction of Professor ...