Browsing by Author "Ann Richmond"
Now showing items 1-20 of 25
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Greenplate, Allison Rae (2018-03-29)Department: Microbiology and ImmunologyThe immune system is a complex network of cells spread throughout the body, spanning dozens of tissue types and locations. A complete understanding of a systemic immune response, like those required for the regression of ...
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Vollbrecht, Peter John (2014-04-17)Department: NeuroscienceBoth dopamine and glutamate are critically involved in cognitive processes such as working memory. Evidence has demonstrated that manipulation of either neurotransmitter can lead to alterations in the other. Astrocytes, ...
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DeBusk, Laura M (2008-04-28)Department: Cancer BiologyWe have identified a novel signaling pathway, AKT/IKKα/VAV1, which induces endothelial cell survival and motility. Ang1/Tie2 and VEGF/VEGFR signaling activates Akt and induces cell survival. Akt and IKKƒÑ both induce ...
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Hardeman, Keisha Nicole (2017-04-11)Department: Cancer BiologyMelanoma is the deadliest form of skin cancer, and virtually all patients progress on targeted therapies. Dysregulated metabolism has been shown to affect therapy response, so BRAF-mutated melanoma cell line models were ...
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Werdich, Xiang Qi (2005-04-06)Department: Cell and Developmental BiologyHypoxia inducible vascular endothelial growth factor (VEGF) plays a major role in initiation and regulation of retinal neovascularization, which is the leading cause of severe vision loss and irreversible blindness in ...
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He, Wenjuan (2010-08-02)Department: Molecular Physiology and BiophysicsSirtuin 1 (Sirt1) is a NAD+-dependent deacetylase that exerts many of the pleiotropic effects of oxidative metabolism. Due to local hypoxia and hypertonicity, the renal medulla is subject to extreme oxidative stress. Here, ...
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Hutchinson, Katherine Emily (2015-03-06)Department: Cancer BiologySolid tumor treatment paradigms have drastically improved in recent decades through direct targeting of the protein products of somatic, constitutively active “driver” mutations and their effector signaling pathways. Prior ...
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Saxon, Jamie Ausborn (2016-02-19)Department: Cancer BiologyNuclear factor κ-light chain enhancer of activated B cells (NF-κB) is a transcription factor that can be activated through canonical or non-canonical signaling pathways, and activation of both pathways has been observed ...
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Lu, Xinyuan (2013-07-26)Department: Cancer BiologyLZAP (Cdk5rap3, C53) is a putative tumor suppressor lost in 30% of human head and neck squamous cell carcinoma. LZAP depletion enhances cell invasion, xenograft tumor growth and angiogenesis. Mechanistically, LZAP inhibits ...
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Multiplex biomaterial matrix cues regulate redox status and stemness in human mesenchymal stem cells Crowder, Spencer William (2014-04-26)Department: Biomedical EngineeringHuman mesenchymal stem cells (hMSCs) offer therapeutic potential for clinical applications but exhibit a decline in overall health when isolated from aging patients or serially expanded in vitro. hMSCs have been shown to ...
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Reiner, Jennifer Elisabeth (2011-06-30)Department: Cancer BiologyThe serine threonine kinase receptor-associated protein (STRAP) is a WD40 domain protein that regulates a wide array of biological processes. Previous reports suggest that STRAP possesses oncogenic characteristics and ...
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Sakrikar, Dhananjay (2012-04-05)Department: NeuroscienceAttention-Deficit Hyperactivity Disorder (ADHD) is the most commonly diagnosed disorder of school-age children. Although genetic and brain imaging studies suggest a contribution of altered dopamine (DA) signaling to ADHD, ...
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Zhuang, Guanglei (2010-04-10)Department: Cancer BiologyThe Eph family of receptor tyrosine kinases has important roles in multiple aspects of cancer development and progression. Substantial advances have been made in understanding the Eph receptor signalling in the pathways ...
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Doxie, Deon Bryant (2018-06-18)Department: Cell and Developmental BiologySingle cell tools have great potential to characterize mechanisms of oncogenesis and treatment resistance. To date, single cell quantitative cytometry has been widely applied in the setting of blood cancer. However, few ...
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Neel, Nicole Fowler (2008-03-06)Department: Cancer BiologyChemokines are a family of small chemotactic cytokines that bind seven transmembrane G protein-coupled receptors. Roles for CXC chemokines and the receptors CXCR2 and CXCR4 in inflammation-mediated tumorigenesis, angiogenesis, ...
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Gordy, Laura Elizabeth (2012-04-19)Department: Microbiology and ImmunologyNatural killer T (NKT) cells are innate-like lymphocytes that develop and mature in the thymus. From there, they home to the peripheral lymphoid tissues where, in some cases, they can finalise the maturation program. NKT ...
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Russell, Alisha Joy (2010-08-25)Department: Cancer BiologyC/EBPbeta is essential for mammary gland growth and development and has been associated with poor prognosis in breast cancer. Overexpression of C/EBPbeta2 in MCF10A cells, a model of normal mammary epithelial cells, results ...
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Fang, Wei Bin (2008-08-25)Department: Cancer BiologyThe EphA2 receptor belongs to the recently cloned Eph family of receptor tyrosine kinase (RTK). High levels of EphA2 RTK have been detected in 60-90% of human breast cancer specimens, both in breast cancer cells and in ...
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Capozzi, Megan Elise (2016-12-15)Department: Molecular Physiology and BiophysicsDiabetic retinopathy (DR) is the leading cause of blindness in working age Americans. The early stages of DR pathogenesis include chronic inflammation, which can eventually lead to the development of later stages of the ...
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Thu, Yee Mon (2011-10-03)Department: Cancer BiologyNuclear factor-êB (NF-êB) inducing kinase (NIK) is a MAP3K that regulates activation of NF-êB. NIK is often over-expressed in tumor cells, including melanoma, but the significance of this in melanoma progression remains ...