Browsing by Author "Andries Zijlstra"
Now showing items 1-16 of 16
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Hebron, Katie Elizabeth (2018-03-27)Department: Cancer BiologyMetastasis persists as a significant unsolved hurdle in cancer treatment, with greater than 90% of cancer-related deaths attributed to metastasis. In order for cells to successfully metastasize, they must dynamically ...
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Irvin, Michael Warren (2012-01-25)Department: Biomedical EngineeringThis project is concerned with in vitro assays of angiogenesis and how mechanical stimuli are controllably incorporated into them. The vascular explant assay is considered the most physiologically realistic in vitro ...
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Hover, Laura Debra (2015-12-16)Department: PathologyImproved therapies for high grade gliomas (HGG) are urgently needed, as the median survival for grade IV gliomas is just 15 months after treatment with surgery, chemotherapy and radiation. Recently, bone morphogenetic ...
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Abreu, Maria Mercedes (2012-05-03)Department: Cancer BiologyC/EBPbeta is a member of a family of basic-leucine zipper transcription factors. It has been shown to be a key regulator of growth and differentiation in the mammary gland. There are three different protein isoforms of ...
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Jovanovic, Bojana Jason (2014-07-23)Department: Cancer BiologyThere is a major need to better understand the molecular basis of triple negative breast cancer (TNBC) in order to develop effective therapeutic strategies. Using gene expression data from 587 TNBC patients we previously ...
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Hariri, Ghazal (2014-12-03)Department: Chemical and Physical BiologyCurrent chemotherapeutic treatments for cancer utilize systemic administration of cytotoxic drugs and produce many side effects in healthy tissues, making optimal treatment of cancer hard to achieve. Tumor targeted ...
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Pickup, Michael William (2013-10-11)Department: Cancer BiologyDissertation under the direction of Professor Harold L. Moses Transforming Growth Factor Beta (TGF-β) is acts as both a tumor suppressor and promoter in the context of epithelial tumor progression. In epithelial cells, ...
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Loomans, Holli Ann (2017-05-11)Department: Cancer BiologyIt was been well established that the Activin A signaling pathway plays a pivotal role in the developing, adult, and diseased organism, commonly acting as a growth inhibitor. Though prevalent in embryonic tissues, Activin ...
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Alfaro, Maria Paula (2011-04-04)Department: PathologyBone marrow-derived mesenchymal stem cells (MSCs) are an attractive candidate for cell-mediated wound repair. Due to their plasticity, MSCs have been utilized in several preclinical and clinical trials of tissue regeneration. ...
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Fey, Erin Elizabeth (2019-10-29)Department: PathologyHeterogeneity in estrogen receptor positive breast cancers is poorly understood. Copy number alterations and structural differences contribute to carcinogenesis. Current cell line genomes representing the histological ...
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Tripathi, Manisha (2011-01-31)Department: Cancer BiologyProstate cancer is the second most common form of cancer in men. Despite the alarming figures and decades of research, a cure still eludes prostate cancer patients. The morbidity associated with advanced prostate cancer ...
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Tran, Thuy Thanh Thi (2011-12-12)Department: PathologyIn this dissertation, I examined the function of the alpha2beta1 integrin in epithelial tumor cells as well as in the tumor microenvironment. The alpha2beta1 integrin is a surface heterodimeric receptor found on epithelial, ...
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Ludwik, Katarzyna Anna (2018-04-11)Department: PathologyThe family of ribosomal S6 Ser/Thr protein kinases (RSK) controls proliferation, viability and motility and, therefore, contributes to the etiology of numerous cancers, including breast. We found that RSK2 is an obligate ...
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Marjoram, Robin James (2011-02-25)Department: PathologyCellular adhesions to the extracellular matrix (ECM) and to neighboring cells are vital interactions within metazoans. This dissertation examines cellular adhesion by utilizing the adhesive interaction between platelets ...
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Mrozowski, Roman Michal (2015-07-21)Department: PathologyRSK is a family of four Ser/Thr protein kinases activated by ERK1/2 signaling. RSK is often misregulated in a variety of cancers, including breast and prostate. More recently, RSK1 and RSK2 have been shown to promote ...
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Campbell, James Preston (2012-11-20)Department: PharmacologyMetastases are the primary cause of death in breast cancer patients, most often appearing in the bones. Following treatment of the primary cancer, emotional and psychosocial factors within this population hasten time to ...