Browsing by Author "Andrea Page-McCaw"
Now showing items 1-16 of 16
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Diggins, Nicole Lee (2018-02-14)Department: Biological SciencesCell migration is vital to numerous biological processes, and is misregulated in pathological processes, such as cancer metastasis. Cell migration is a tightly, spatiotemporally regulated process that requires the coordination ...
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Neitzel, Leif Richard (2018-08-28)Department: Cell and Developmental BiologyCell division cycle 14 (Cdc14) is an evolutionarily conserved phosphatase originally identified in <em>Saccharomyces cerevisiae</em> as a cell cycle regulator. In <em>Drosophila melanogaster</em>, Cdc14 is encoded by a ...
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Broderick, Sarah M (2013-04-19)Department: Cell and Developmental BiologyNinjurins are a conserved family of transmembrane proteins that increase expression in response to injury and stress. There are few in vivo studies of Ninjurin, and little is known about Ninjurin function. In this thesis ...
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Walter, Teagan Jo (2013-12-09)Department: Cell and Developmental BiologyDuring liver development, precise signaling is required to direct cell fate decisions and architectural establishment. It is hypothesized that the same signaling pathways are important in directing liver regeneration. To ...
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Riley, Kimberly Ann Gooding (2015-03-25)Department: Cell and Developmental BiologyAs diabetes continues to affect millions of people within the United States, identification of novel factors that may enhance beta-cell proliferation and mass regeneration in vivo is critical. Our lab previously demonstrated ...
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Ngn3-expressing progenitor heterogeneity drives endocrine lineage allocation in pancreas development Liu, Jing (2015-11-17)Department: Cell and Developmental BiologyDiabetes is a worldwide health issue. In both type I and late stage type II diabetes, significant beta-cell loss causes insulin deficiency and hyperglycemia. Replenishing beta cells is a promising therapy and it requires ...
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Hainline, Sarah Grace (2014-08-18)Department: Cell and Developmental BiologyIn a biochemical screen Anaphase-Promoting Complex (APC) substrates, we identified Drosophila MCPH1 isoform B (dMCPH1-B) as a substrate of APCCdh1. dMCPH1-B undergoes Cdh1-dependent degradation in Xenopus egg extract, which ...
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Merkle, Julie Ann (2011-07-25)Department: Cell and Developmental BiologyIn a screen for cell-cycle regulators, we identified a Drosophila maternal effect-lethal mutant that we named “no poles” (nopo). Embryos from nopo females undergo mitotic arrest with barrel-shaped, acentrosomal spindles ...
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Nielsen, Casey Paulasue (2019-09-09)Department: Cell and Developmental BiologyThe WNT signaling network is comprised of multiple receptors that relay various input signals via distinct transduction pathways to execute multiple complex and context-specific output processes. Integrity of the WNT ...
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Saito-Diaz, Vicente Kenyi (2017-03-27)Department: Cell and Developmental BiologyThe Wnt pathway is a highly-conserved pathway that controls many developmental processes and is mutated in many human diseases (e.g., cancer). The tumor suppressor adenomatous polyposis coli (APC) is a critical negative ...
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League, Garrett Philip (2017-03-24)Department: Biological SciencesMosquitoes encounter pathogens throughout their holometabolous life cycle, be it in the microbe-rich pools of the aquatic larva stage or the infected blood meals of the terrestrial adult stage. Pathogens that invade the ...
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LePage, Daniel Paul (2016-07-11)Department: Biological SciencesWolbachia pipientis arguably constitute the largest pandemic of the animal kingdom. Estimated to infect 40% of all arthropod species, these obligate intracellular bacteria are masterful controllers of host reproduction and ...
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Stevens, Laura Jeanette (2012-03-15)Department: Cell and Developmental BiologyWound healing, an essential function to the survival of all multicellular organisms, requires the precise orchestration of multiple cell types in order to repair the damaged tissue. Wound healing involves three overlapping ...
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Sanders, Lehanna Nalani (2016-06-02)Department: Cell and Developmental BiologyCELL AND DEVELOPMENTAL BIOLOGY The role of the BMP antagonist Gremlin2 during cardiac tissue repair Lehanna Nalani Sanders Dissertation under the direction of Professor Antonis Hatzopoulos Acute myocardial infarction ...
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Fleming, Jonathan Tyler (2014-04-30)Department: Cell and Developmental BiologySonic hedgehog (Shh) signaling regulates critical processes during embryonic development and in homeostasis of adult tissues. Deregulated pathway activity is a major factor underlying the etiology of numerous developmental ...
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Guyer, Richard Allen (2015-07-17)Department: Cell and Developmental BiologyProteins that regulate cell polarity are fundamental for metazoan biology and are necessary for proper development of tissues and organs. In light of polarity genes’ fundamental role in tissue organization, disruptions ...