Browsing by Author "Amy Major"
Now showing items 1-9 of 9
-
Carrillo, Alexia Melo (2014-08-15)Department: PathologyThe oncogenes Mdm2 and Mdmx are often overexpressed in many human cancers. In addition to being negative regulators of the tumor suppressor p53, there is evidence these proteins have important p53-independent functions ...
-
Stocks, Blair Taylor (2016-07-24)Department: Microbiology and ImmunologyAchieving transplant tolerance in the autoimmune environment will require targeting multiple immunologic dysregulations in T-B lymphocyte collaboration that drive the aggressive anti-graft response. At a biologic level, ...
-
Gutierrez, Dario Alejandro (2012-03-29)Department: Molecular Physiology and BiophysicsObesity is closely linked to many metabolic diseases such as insulin resistance (IR), type 2 diabetes mellitus and cardiovascular disease. In the past decade, it has been established that immune cells are recruited to ...
-
Buckman, Laura Beth (2014-06-27)Department: Molecular Physiology and BiophysicsIn the past decade, evidence has emerged that obesity induces a neuroinflammatory response in the hypothalamus, a part of the brain that contains neuronal circuitry controlling feeding and metabolism. The potential ...
-
Gibbons, Hunter Ramsdell (2019-10-15)Department: Microbiology and ImmunologyNaïve CD4+ T cells polarize into many varied CD4+ T-helper (TH) cell subsets depending on the cytokine milieu present during T cell receptor stimulation. Each T cell subset produces a unique cytokine profile to defend ...
-
Anderson, Emily Kathleen (2013-04-11)Department: Molecular Physiology and BiophysicsObesity is a prevalent disorder that increases the risk of developing many metabolic diseases, including insulin resistance (IR) and type 2 diabetes. Research conducted in the past decade has shown that accumulation of ...
-
Wasson Surmi, Bonnie Kae (2009-12-11)Department: Molecular Physiology and BiophysicsObesity is a strong risk factor for type 2 diabetes and cardiovascular disease partly because of the changes that occur in white adipose tissue (WAT) during weight gain. As obesity progresses, WAT expands, becomes ...
-
Rabacal, Whitney Amber Sachi (2016-08-18)Department: Microbiology and ImmunologyThe immune system is charged with the task of protecting the body from pathogens and clearing apoptotic or cancerous cells to prevent chronic disease. Controlled cell migration shapes lymphocyte subset development, ...
-
Collier, Sarah Parker (2014-03-28)Department: Microbiology and ImmunologyThousands of genes encoding long noncoding RNAs were identified throughout the genome; however, less than 1% of known long noncoding RNAs have been assigned a biologic function. At present, long noncoding RNAs mediate ...