Browsing by Subject "breast cancer"
Now showing items 41-54 of 54
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(2021-03-29)Department: Cancer BiologyBone is a common site of metastasis for advanced breast, prostate, and lung cancer. Most patients with skeletal metastases develop tumor-induced bone disease (TIBD), which is characterized by a vicious cycle of tumor growth ...
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(2015-11-24)Department: PharmacologyMalignant cancers are the second leading cause of death in the United States, with a projected 1.6 million new diagnoses per year and almost 600,000 deaths. Our understanding of the molecular pathways causing tumor initiation, ...
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(2015-08-03)Department: Biomedical InformaticsMonitoring quality metrics continuously in breast cancer care can help healthcare providers and organizations engage with patients, advance the delivery of care, and tackle financial challenges. In this work, we develop ...
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(2014-12-02)Department: Cancer BiologyBreast cancer is the leading cancer diagnosis in pre-menopausal women in the U.S. Of these breast cancers, 25% are diagnosed 2-5 years post-partum. Unfortunately, post-partum breast cancers (ppBCs) are highly metastatic. ...
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(2016-03-30)Department: Cancer BiologyDysregulation of receptor tyrosine kinases (RTKs) contributes to cellular transformation and cancer progression by disrupting key metabolic signaling pathways. The EPHA2 RTK is overexpressed in aggressive forms of breast ...
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(2016-03-17)Department: Cancer BiologyEpithelial cancers of the lung, colon, breast, and pancreas comprise the top four most deadly cancers. Progress has been made in treating primary epithelial tumors, however metastatic tumors remain largely incurable and ...
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(2014-07-22)Department: PathologyAlthough the MYC transcription factor was discovered over three decades ago and is dysregulated in the majority of human cancers, its regulation remains incompletely understood and there is no pharmacologic means to inhibit ...
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(2010-08-25)Department: Cancer BiologyC/EBPbeta is essential for mammary gland growth and development and has been associated with poor prognosis in breast cancer. Overexpression of C/EBPbeta2 in MCF10A cells, a model of normal mammary epithelial cells, results ...
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(2015-07-09)Department: Cancer BiologyCANCER BIOLOGY The role of mTORC2 in mammary morphogenesis and HER2-mediated tumorigenesis Meghan Melinda Morrison Dissertation under the direction of Professor Rebecca Cook The phosphatidyl inositol-3-kinase (PI3K)/Akt ...
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(2012-04-04)Department: Cancer BiologyCadherins and catenins are important regulators of tissue homeostasis and cancer. Here, we report critical roles for p120 catenin (p120) in mammary development and breast cancer. In the untransformed gland, p120 ablation ...
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(2024-03-20)Department: Biomedical EngineeringBreast cancer is the second-highest cancer occurrence in women in the United States and is the most prevalent cancer worldwide, with many studies dedicated to understanding its characteristics. In addition to examining ...
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(2024-03-20)Department: Biomedical EngineeringBreast cancer is the second-highest cancer occurrence in women in the United States and is the most prevalent cancer worldwide, with many studies dedicated to understanding its characteristics. In addition to examining ...
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(2020-08-18)Department: EpidemiologyGeneral obesity, measured by BMI, have been linked to increased incidence and mortality of certain cancer. However, BMI does not account for body composition and could not differentiate between muscle mass and fat. I ...
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(2006-12-19)Department: Biomedical EngineeringThe collection of visual evidence of M13 bacteriophage displaying a nuclear localization heptapeptide localizing to the nuclei of breast cancer cells is described in this thesis. The bacteriophages displaying the heptapeptide ...