Browsing by Title
Now showing items 10589-10608 of 17877
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(2017-04-01)Department: Biomedical EngineeringWith the rapid emergence of antibiotic-resistant bacteria and the lack of antibiotics in the development pipeline, bacteremia and sepsis are becoming an increasing health concern. Rapid diagnosis currently suffers from the ...
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(2021-08-16)Department: ChemistryAs a means to prepare enantioenriched small molecules, chiral hydrogen bond catalysts have been developed. These organocatalysts are the latest broad class of reagents for enantioselective reaction development, but they ...
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(2022-06-09)Department: Mechanical EngineeringThe increase in atmospheric greenhouse gas concentrations due to anthropogenic emissions poses imminent threats to Earth’s climate system and its most vulnerable communities. Technological innovation plays a major role in ...
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(2019-04-09)Department: Biomedical EngineeringThe increased incidence of antibiotic-resistant bacteria, like methicillin-resistant S. aureus, necessitates treatments that prevent the development of further resistance. One method that has shown promise in this regard ...
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(2006-11-20)Department: Chemical EngineeringThis study focused on creating water-based, targeted, nanoparticulate polyelectrolyte complex (PEC) drug delivery vehicles. The polymeric structure of PECs allowed for integration of an anti-angiogenic, heparin binding ...
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Optimization Techniques for Enhancing Middleware Quality of Service for Product-line Architectures (2005-12-01)Department: Computer ScienceProduct-line architectures (PLA)s are an emerging paradigm for developing software families by customizing reusable artifacts, rather than hand-crafting the software from scratch. In this paradigm, each product variant ...
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(2010-11-19)Department: Biomedical EngineeringWith cancer encompassing a range of disease states and phenotypes, assessing treatment efficacy early, accurately, and non-invasively is essential to optimize therapy planning on an individualized basis. This work discusses ...
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Optimization-based approach to cross-layer resource management in Wireless networked control systems (2013-04-18)Department: Electrical EngineeringWireless Networked Control Systems (NCS) are increasingly deployed to monitor and control Cyber-Physical Systems (CPS), as wireless network provides great convenience in terms of fully mobile operation, rapid deployment ...
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(2021-03-25)Department: ChemistrySolvent-based synthesis has been the foundation of chemistry since the inception of synthetic transformations. As chemists become more aware of the chemical and environmental complications that arise from the use and ...
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(2024-03-21)Department: Computer ScienceIn an era where data increasingly drives our world, the proliferation of Artificial Intelligence (AI) is undeniable. AI has become integral, not just in our digital lives but in mission-critical domains from medical ...
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(2020-09-18)Department: Biomedical EngineeringPulsed infrared lasers have been leveraged for inducing temperature mediated block of the propagation of neural signals in a technique called infrared neural inhibition (INI). INI has been shown to selectively block small ...
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(2014-11-24)Department: Civil EngineeringAs water pipelines reach the end of their useful lives, asset managers must develop replacement and maintenance programs that mitigate the risk of pipeline failure. A risk-based asset management program must include ...
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(2013-12-12)Department: Biomedical EngineeringRNA interference (RNAi) by small interfering RNA (siRNA) possesses great promise as a therapeutic for pathologies whose etiology is related to gene overexpression. However, due to the poor pharmacokinetic properties of ...
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(2024-03-04)Department: Biomedical EngineeringTriple negative breast cancer (TNBC) is a highly aggressive BC subtype with limited molecularly targeted therapies. Aberrant activation of the phosphatidylinositol 3-kinase/ mammalian target of rapamycin (PI3K/mTOR) pathway ...
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(2008-11-17)Department: Computer ScienceSoftware Product-Lines (SPLs) are software architectures that provide reusable components that can be configured into variants to meet different requirement sets. A key part of an SPL is a specification of the rules governing ...
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(2017-01-06)Department: Computer ScienceIn the past decade, we have witnessed a rapid growth in the quantity, quality, and diversity of personal data we shed through our daily activities. At the same time, it is increasingly recognized that personal data has ...
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(2015-07-23)Department: Cancer BiologyEGFR-mutant lung cancers are highly sensitive to EGFR tyrosine kinase inhibitors (TKIs; erlotinib/gefitinib/afatinib), but tumors develop drug resistance within 9-16 months. Resistance to gefitinib/erlotinib commonly occurs ...
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(2017-08-29)Department: Cancer BiologyEwing sarcoma is a highly aggressive pediatric bone tumor that is characterized EWS/FLI1 transcription factor. Ewing sarcoma tumors require the continued activity of EWS/FLI1 to sustain a gene signature that promotes ...
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(2011-08-01)Department: Computer ScienceWireless mesh networks have attracted increasing attention and deployment as a high-performance and low-cost solution to last-mile broadband Internet access. The capability of balancing the traffic load along different ...
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(Vanderbilt University, 2008)This paper presents a North-South model of international trade in which (i) there is a relatively small number of countries in the North and (ii) the North is relatively abundant in capital while the South is relatively ...