Targeting MYC through WDR5
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Date
Journal Title
Journal ISSN
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Publisher
Molecular & Cellular Oncology
Abstract
The oncoprotein transcription factor MYC is overexpressed in most cancers and is responsible for hundreds of thousands of cancer deaths worldwide every year. MYC is also a highly validated - but currently undruggable - anti-cancer target. We recently showed that breaking the interaction of MYC with its chromatin co-factor WD repeat-containing protein 5 (WDR5) promotes tumor regression in mouse xenografts, laying the foundation for a new strategy to inhibit MYC in the clinic.
Description
Keywords
Cancer, MYC, WDR5, Cancer therapy
Citation
Lance R. Thomas, Clare M. Adams, Stephen W. Fesik, Christine M. Eischen & William P. Tansey (2020) Targeting MYC through WDR5, Molecular & Cellular Oncology, 7:2, 1709388, DOI: 10.1080/23723556.2019.1709388