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Regeneration of severely damaged lungs using an interventional cross-circulation platform

dc.contributor.authorBacchetta, Matthew
dc.identifier.citationuenthart, B.A., O’Neill, J.D., Kim, J. et al. Regeneration of severely damaged lungs using an interventional cross-circulation platform. Nat Commun 10, 1985 (2019).
dc.description.abstractThe number of available donor organs limits lung transplantation, the only lifesaving therapy for the increasing population of patients with end-stage lung disease. A prevalent etiology of injury that renders lungs unacceptable for transplantation is gastric aspiration, a deleterious insult to the pulmonary epithelium. Currently, severely damaged donor lungs cannot be salvaged with existing devices or methods. Here we report the regeneration of severely damaged lungs repaired to meet transplantation criteria by utilizing an interventional cross-circulation platform in a clinically relevant swine model of gastric aspiration injury. Enabled by cross-circulation with a living swine, prolonged extracorporeal support of damaged lungs results in significant improvements in lung function, cellular regeneration, and the development of diagnostic tools for non-invasive organ evaluation and repair. We therefore propose that the use of an interventional cross-circulation platform could enable recovery of otherwise unsalvageable lungs and thus expand the donor organ pool.en_US
dc.description.sponsorshipThe authors would like to thank A. Griesemer for discussions of the experimental design; D. Sachs for providing research animals; the Institute of Comparative Medicine veterinary staff, including K. Fragoso and A. Rivas for their support of animal studies; L. Cohen-Gould for transmission electron microscopy imaging; the Herbert Irving Comprehensive Cancer Center Molecular Pathology Shared Resources, including T. Wu, D. Sun, and R. Chen for help with analytics; J. Bhattacharya for providing experimental reagents. YW. Chen for live cell imaging. BLES Biochemicals, Inc. provided the bovine lipid extract surfactant used in the study. The authors gratefully acknowledge funding support from the National Institutes of Health (grants HL134760, EB002520, and HL007854), the Richard Bartlett Foundation, and the Mikati Foundation.en_US
dc.languageEnglish United States
dc.publisherNature Communicationsen_US
dc.rightsThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit
dc.subjectDONOR LUNGSen_US
dc.titleRegeneration of severely damaged lungs using an interventional cross-circulation platformen_US

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