Browsing Electronic Theses and Dissertations by Subject "ubiquitin"
Now showing items 1-8 of 8
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(2016-01-13)Department: Cell and Developmental BiologyProper regulation of gene transcription is an essential process for any cell. Failure to precisely control the procedure of transcription can lead to developmental defects, disease, and even death. Within the last 20 years, ...
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(2004-04-08)Department: Cell and Developmental BiologyThe ubiquitin-proteasome pathway (UPP) is the principal mechanism for the selective degradation of short-lived proteins. The proximal signal for UPP-mediated proteolysis is the covalent modification of target proteins with ...
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(2009-04-09)Department: BiochemistryThis study demonstrated the utility of direct tissue MALDI MS in identifying early markers of antibiotic induced nephrotoxicity. Using a histology directed approach, twelve proteins were identified as having statistically ...
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(2012-12-01)Department: PharmacologyStudies described in this thesis identify a novel mechanism for α4’s regulation of PP2Ac stability. α4 binds the PP2A catalytic subunit (PP2Ac) and the microtubule-associated E3 ubiquitin ligase MID1, and through unknown ...
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(2011-08-31)Department: BiochemistryUbiquitination is a post-translational modification, that functions in a variety of cellular signaling pathways. Unlike modification with a small functional group by a single enzyme, modification by the small protein ...
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(2013-07-29)Department: Cell and Developmental BiologyMy study of three signaling pathways in the context of three gastrointestinal diseases is presented here. Firstly, the epidermal growth factor receptor (EGFR) pathway and its role in the pathogenesis of the hypertrophic ...
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(2016-08-31)Department: Cell and Developmental BiologyThe ubiquitin–proteasome system (UPS) influences gene transcription in multiple ways. One way in which the UPS impacts transcription centers on transcriptional activators, the function of which can be stimulated by components ...
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(2011-07-29)Department: Cell and Developmental BiologyEpithelial cells establish apical and basolateral (BL) membranes with distinct protein and lipid compositions. To achieve this spatial asymmetry, the cell utilizes a variety of mechanisms for differential sorting, delivery ...