Browsing Electronic Theses and Dissertations by Subject "mouse model"
Now showing items 1-7 of 7
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(2019-07-24)Department: NeuroscienceFoxg1 Disorder is a rare yet devastating neurodevelopmental disorder that is characterized by intellectual, motor, and social deficits as well as seizures. It is accompanied by neuroanatomical abnormalities. The protein ...
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(2015-03-25)Department: NeuroscienceApproximately 25% of individuals with autism spectrum disorder (ASD) possess elevated whole blood serotonin (5-HT) levels, termed hyperserotonemia. However, the connection between this biomarker and the pathophysiology of ...
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(2019-04-02)Department: NeuroscienceEpileptic encephalopathies (EEs) are catastrophic childhood epilepsies with intractable seizures, developmental delays, and cognitive impairment. I determined the functional impact of five de novo GABAA receptor β subunit ...
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(2014-10-29)Department: NeuroscienceEpilepsy is a common neurological disease characterized by an enduring predisposition to generate seizures. Although multiple factors contribute to epilepsy, the majority of cases are genetic in origin. Variable expressivity ...
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(2008-05-30)Department: BiochemistryHistone deacetylase 3 (HDAC3) is the enzymatic component of transcriptional repression complexes recruited by the nuclear hormone receptors. Inactivation of HDAC3 in cancer cell lines triggered apoptosis, and removal of ...
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(2020-02-14)Department: BiochemistryRegulation of iron homeostasis is perturbed in numerous pathologic states. Thus, identifications of mechanisms responsible for iron metabolism have broad implication for disease modification. Sulfur assimilation is an ...
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(2012-07-26)Department: Cancer BiologyTransforming growth factor-beta (TGF-β) has a dual role during tumor progression initially as a suppressor and then as a promoter. Much is known about the contribution of TGF-β signaling to tumorigenesis, yet, the role ...