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Structure of the Helicobacter pylori Cag type IV Secretion System

dc.contributor.authorCampbell, Anne M.
dc.contributor.authorChung, Jeong Min
dc.contributor.authorSheedlo, Michael J.
dc.contributor.authorSawhney, Neha
dc.contributor.authorFrick-Cheng, Arwen E.
dc.contributor.authorLacy, Dana Borden
dc.contributor.authorCover, Timothy L.
dc.contributor.authorOhi, Melanie D.
dc.identifier.citationeLife 2019;8:e47644 doi: 10.7554/eLife.47644en_US
dc.description.abstractBacterial type IV secretion systems (T4SSs) are molecular machines that can mediate interbacterial DNA transfer through conjugation and delivery of effector molecules into host cells. The Helicobacter pylori Cag T4SS translocates CagA, a bacterial oncoprotein, into gastric cells, contributing to gastric cancer pathogenesis. We report the structure of a membrane-spanning Cag T4SS assembly, which we describe as three sub-assemblies: a 14-fold symmetric outer membrane core complex (OMCC), 17-fold symmetric periplasmic ring complex (PRC), and central stalk. Features that differ markedly from those of prototypical T4SSs include an expanded OMCC and unexpected symmetry mismatch between the OMCC and PRC. This structure is one of the largest bacterial secretion system assemblies ever reported and illustrates the remarkable structural diversity that exists among bacterial T4SSs.en_US
dc.description.sponsorshipNational Institute of Allergy and Infectious Diseases AI118932 Timothy L Cover Melanie D Ohi National Cancer Institute CA116087 Timothy L Cover U.S. Department of Veterans Affairs 1I01BX004447 Timothy L Cover National Institute of General Medical Sciences GM103310 Melanie D Ohien_US
dc.rights© 2019, Chung et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
dc.subject.lcshHelicobacter pylorien_US
dc.titleStructure of the Helicobacter pylori Cag type IV Secretion Systemen_US

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