Browsing Research reports by Subject "fluorescence polarization"

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    • The anti-parasitic agent suramin and several of its analogues are inhibitors of the DNA binding protein Mcm10 
      Paulson, Carolyn N.; John, Kristen; Baxley, Ryan M.; Kurniawan, Fredy; Orellana, Kayo; Francis, Rawle; Sobeck, Alexandra; Eichman, Brandt F.; Chazin, Walter J.; Aihara, Hideki; Georg, Gunda I.; Hawkinson, Jon E.; Bielinsky, Anja-Katrin (Open Biology, 2019-08)
      Minichromosome maintenance protein 10 (Mcm10) is essential for DNA unwinding by the replisome during S phase. It is emerging as a promising anti-cancer target as MCM10 expression correlates with tumour progression and poor ...