Browsing Research publications by Subject "KINASE"

Now showing items 1-1 of 1

    • The CDK7 Inhibitor THZ1 Alters RNA Polymerase Dynamics at the 5 ' and 3 ' Ends of Genes 
      Sampathi, Shilpa; Acharya, Pankaj; Zhao, Yue; Wang, Jing; Stengel, Kristy; Liu, Qi; Savona, Michael R.; Hiebert, Scott W. (NUCLEIC ACIDS RESEARCH, 2019-05)
      The t(8;21) is one of the most frequent chromosomal translocations associated with acute myeloid leukemia (AML). We found that t(8; 21) AML were extremely sensitive to THZ1, which triggered apoptosis after only 4 h. We ...