Now showing items 1-5 of 5
Estimates of the Prevalence of Speech and Motor Speech Disorders in Adolescents with Down syndrome
(CLINICAL LINGUISTICS & PHONETICS, 2019-08)
Although there is substantial rationale for a motor component in the speech of persons with Down syndrome (DS), there presently are no published estimates of the prevalence of subtypes of motor speech disorders in DS. The ...
Dual roles for the ER Membrane Protein Complex in Flavivirus Infection: Viral Entry and Protein Biogenesis
(SCIENTIFIC REPORTS, 2019-07-04)
Hundreds of cellular host factors are required to support dengue virus infection, but their identity and roles are incompletely characterized. Here, we identify human host dependency factors required for efficient dengue ...
Structure of the Helicobacter pylori Cag type IV Secretion System
Bacterial type IV secretion systems (T4SSs) are molecular machines that can mediate interbacterial DNA transfer through conjugation and delivery of effector molecules into host cells. The Helicobacter pylori Cag T4SS ...
In Situ Molecular Architecture of the Helicobacter pylori Cag Type IV Secretion System
Helicobacter pylori colonizes about half of humans worldwide, and its presence in the gastric mucosa is associated with an increased risk of gastric adenocarcinoma, gastric lymphoma, and peptic ulcer disease. H. pylori ...
Loss of Function of Colgant1 Disrupts Collagen Post-translationa Modification and Causes Musculoskeletal Defects
(DISEASE MODELS & MECHANISMS, 2019-06)
In a screen for organogenesis defects in N-ethyl-N-nitrosourea (ENU)-induced mutant mice, we discovered a line carrying a mutation in Colgaft1 [collagen beta(1-O)galactosyltransferase type 1], which is required for proper ...