Now showing items 72-75 of 75

    • Aho, Erin R.; Weissmiller, April M.; Fesik, Stephen W.; Tansey, William P. (EPIGENETICS INSIGHTS, 2019-07-18)
      WDR5 is a component of multiple epigenetic regulatory complexes, including the mixed lineage leukemia (MLL)/SET complexes that deposit histone H3 lysine 4 methylation. Inhibitors of an arginine-binding cavity in WDR5, known ...
    • Indurthi, Venkata S. K.; Jensen, Jaime L.; Leclerc, Estelle; Sinha, Sangita; Colbert, Christopher L.; Vetter, Stefan W. (Bioscence Reports, 2020-01-30)
      The receptor for advanced glycation end products (RAGE) recognizes damage-associated molecular patterns (DAMPs) and plays a critical role for the innate immune response and sterile tissue inflammation. RAGE overexpression ...
    • Nielsen, Casey P.; Jemigan, Kristin K.; Diggins, Nicole L.; Webb, Donna J.; MacGurn, Jason A. (Cell Reports, 2019-07-23)
      The WNT signaling network is comprised of multiple receptors that relay various input signals via distinct transduction pathways to execute multiple complex and context-specific output processes. Integrity of the WNT ...
    • Itthipuripat, Sirawaj; Sprague, Thomas C.; Serences, John T. (PLOS Biology, 2019-08)
      When a behaviorally relevant stimulus has been previously associated with reward, behavioral responses are faster and more accurate compared to equally relevant but less valuable stimuli. Conversely, task-irrelevant stimuli ...