Now showing items 34-53 of 75

    • Ferguson, Michael A.; Lim, Chun; Cooke, Danielle; Darby, R. Ryan; Wu, Ona; Rost, Natalia S.; Corbetta, Maurizio; Grafman, Jordan; Fox, Michael D. (NATURE COMMUNICATIONS, 2019-08-02)
      Human memory is thought to depend on a circuit of connected brain regions, but this hypothesis has not been directly tested. We derive a human memory circuit using 53 case reports of strokes causing amnesia and a map of ...
    • Cao, Jing; Yang, Rong; Smith, Taylor E.; Evans, Stephanie; McCollum, Gary W.; Pomerantz, Steven C.; Petley, Theodore; Harris, Ian R.; Penn, John S. (Molecular Therapy-Methods & Clinical Development, 2019-09-13)
      Exudative age-related macular degeneration (AMD), characterized by choroidal neovascularization (CNV), is the leading cause of irreversible blindness in developed countries. Anti-vascular endothelial growth factor (VEGF) ...
    • Phillips, Elizabeth Jane; Mallal, Simon Alexander (Nature Communications, 2019-08-08)
      Drug hypersensitivity such as severe cutaneous adverse reactions (SCAR), including Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), could be life-threatening. Here, we enroll SCAR patients to investigate ...
    • Schey, Kevin L.; Wang, Zhen; Rose, Kristie L.; Anderson, David M. G. (Cells, 2023-01-13)
      Age-related protein truncation is a common process in long-lived proteins such as proteins found in the ocular lens. Major truncation products have been reported for soluble and membrane proteins of the lens, including ...
    • Giganti, Mark J.; Shepherd, Bryan E.; Caro-Vega, Yanink; Luz, Paula M.; Rebeiro, Peter F.; Maia, Marcelle; Julmiste, Gaetane; Cortes, Claudia; McGowan, Catherine C.; Duda, Stephany N. (BMC Public Health, 2019-12-30)
      Background: Data audits are often evaluated soon after completion, even though the identification of systematic issues may lead to additional data quality improvements in the future. In this study, we assess the impact of ...
    • Hu, Bo; Khara, Pratick; Song, Liqiang; Lin, Aung Soe; Frick-Cheng, Arwen E.; Harvey, M. Lorena; Cover, Timothy L.; Christie, Peter J. (MBIO, 2019-05)
      Helicobacter pylori colonizes about half of humans worldwide, and its presence in the gastric mucosa is associated with an increased risk of gastric adenocarcinoma, gastric lymphoma, and peptic ulcer disease. H. pylori ...
    • Weissmiller, April M.; Wang, Jing; Lorey, Shelly L.; Howard, Gregory C.; Martinez, Ernest; Liu, Qi; Tansey, William P. (Nature Communications, 2019-05-01)
      SMARCB1 encodes the SNF5 subunit of the SWI/SNF chromatin remodeler. SNF5 also interacts with the oncoprotein transcription factor MYC and is proposed to stimulate MYC activity. The concept that SNF5 is a coactivator for ...
    • Albertolle, Matthew E.; Glass, Sarah M.; Trefts, Elijah; Guengerich, F. Peter (Journal of Biological Chemistry, 2019-04-19)
      Oxidative modifications of cysteine residues are an important component in signaling pathways, enzymatic regulation, and redox homeostasis. Current direct and indirect methods detect specific modifications and a general ...
    • Ye, Xiang; Zhao, Yang; Karijolich, John (PLOS Pathogens, 2019-06)
      Precise promoter annotation is required for understanding the mechanistic basis of transcription initiation. In the context of complex genomes, such as herpesviruses where there is extensive genic overlap, identification ...
    • Geister, Krista A.; Lopez-Jimenez, Alberto Jose; Houghtaling, Scott; Ho, Tzu-Hua; Vanacore, Roberto; Beier, David R. (DISEASE MODELS & MECHANISMS, 2019-06)
      In a screen for organogenesis defects in N-ethyl-N-nitrosourea (ENU)-induced mutant mice, we discovered a line carrying a mutation in Colgaft1 [collagen beta(1-O)galactosyltransferase type 1], which is required for proper ...
    • Butler, Andrew A.; Zhang, Jinsong; Price, Candice A.; Stevens, Joseph R.; Graham, James L.; Stanhope, Kimber L.; King, Sarah; Krauss, Ronald M.; Bremer, Andrew A.; Havel, Peter J. (JOURNAL OF BIOLOGICAL CHEMISTRY, 2019-06-21)
      Mouse studies linking adropin, a peptide hormone encoded by the energy homeostasis-associated (ENHO) gene, to biological clocks and to glucose and lipid metabolism suggest a potential therapeutic target for managing diseases ...
    • Werede, Ayoda T. T.; Terry, James G. G; Nair, Sangeeta; Temu, Tecla M. M.; Shepherd, Bryan E. E.; Bailin, Samuel S. S.; Mashayekhi, Mona; Gabriel, Curtis L. L.; Lima, Morgan; Woodward, Beverly Owen; Hannah, LaToya; Mallal, Simon A. A.; Beckman, Joshua A. A.; Li, Jonathan Z. Z.; Fajnzylber, Jesse; Harrison, David G. G.; Carr, John Jeffrey; Koethe, John R. R.; Wanjalla, Celestine N. N. (Journal Of The American Heart Association, 2022-12-06)
      BackgroundPersons with HIV have a higher prevalence of coronary artery disease compared with their HIV-negative counterparts. Earlier identification of subclinical atherosclerosis may provide a greater opportunity for ...
    • Creed, Jordan H.; Peeri, Noah C.; Anic, Gabriella M.; Thompson, Reid C.; Olson, Jeffrey J.; LaRocca, Renato, V.; Chowdhary, Sajeel A.; Brockman, John D.; Gerke, Travis A.; Nabors, Louis B.; Egan, Kathleen M. (Scientific Reports, 2019-07-26)
      Methylmercury (MeHg) is an environmental neurotoxin with human exposure mainly from dietary intake of contaminated fish. Exposure to MeHg has been implicated in neurological damage, but research on its role in cancers, ...
    • Antunes, Krist Helen; Fachi, Jose Luis; de Paula, Rosemeire; da Silva, Emanuelle; Pral, Lais Passariello; dos Santos, Adara Aurea; Dias, Greicy Brisa Malaquias; Vargas, Jose Eduardo; Puga, Renato; Mayer, Fabiana Quoos (Nature Communications, 2019-07-22)
      Severe respiratory syncytial virus (RSV) infection is a major cause of morbidity and mortality in infants <2 years-old. Here we describe that high-fiber diet protects mice from RSV infection. This effect was dependent on ...
    • Strothman, Claire; Farmer, Veronica; Arpag, Goker; Rodgers, Nicole; Podolski, Marija; Norris, Stephen; Ohi, Ryoma; Zanic, Marija (Journal of Cell Biology, 2019-09)
      Dynamic organization of microtubule minus ends is vital for the formation and maintenance of acentrosomal microtubule arrays. In vitro, both microtubule ends switch between phases of assembly and disassembly, a behavior ...
    • Euliano, Erin M.; Hardcastle, Austin N.; Victoriano, Christie M.; Gabella, William E.; Haselton, Frederick R.; Adams, Nicholas M. (Scientific Reports, 2019-08-06)
      Reverse transcription polymerase chain reaction (RT-PCR) is the gold standard for the molecular diagnosis of many infectious diseases, including RNA viruses, but is generally limited to settings with access to trained ...
    • Wen, Hui-Ju; Gao, Shan; Wang, Yin; Ray, Michael; Magnuson, Mark A.; Wright, Christopher V. E.; Di Magliano, Marina Pasca; Frankel, Timothy L.; Crawford, Howard C. (Cellular and Molecular Gastroenterology and Hepatology, 2019)
      BACKGROUND & AIMS: Pancreatitis is a major cause of morbidity and mortality and is a risk factor for pancreatic tumorigenesis. Upon tissue damage, an inflammatory response, made up largely of macrophages, provides multiple ...
    • Mar, Philip L.; Raj, Satish R. (Frontiers in Physiology, 2019-07-30)
      [This corrects the article DOI: 10.3389/fphys.2014.00220.]. http://hdl.handle.net/1803/10006
    • Raju, Nagarajan; Zhan, Xiaoyan; Das, Subash; Karwal, Lovkesh; Dean, Hansi J.; Crowe Jr, James E.; Carnahan, Robert H.; Georgiev, Ivelin S. (Cell Reports, 2022-12-13)
      Dengue is a major public health threat. There are four dengue virus (DENV) serotypes; therefore, efforts are focused on developing safe and effective tetravalent DENV vaccines. While neutralizing antibodies contribute to ...
    • Gobert, Alain P.; Asim, Mohammad; Smith, Thaddeus M.; Williams, Kamery J.; Barry, Daniel P.; Allaman, Margaret M.; McNamara, Kara M.; V. Hawkins, Caroline; Delgado, Alberto G.; Piazuelo, M. Blanca; Rathmacher, John A.; Wilson, Keith T. (Biomedicine & Pharmacotherapy, 2022-12-06)
      Stomach cancer is a leading cause of cancer death. Helicobacter pylori is a bacterial gastric pathogen that is the primary risk factor for carcinogenesis, associated with its induction of inflammation and DNA damage. ...