Browsing Cardiovascular Medicine by Title

Now showing items 23-24 of 24

    • Use of Genetic Variants Related to Antihypertensive Drugs to Inform on Efficacy and Side Effects 
      Gill, Dipender; Georgakis, Marios K.; Koskeridis, Fotios; Jiang, Lan; Feng, Qiping; Wei, Wei-Qi; Theodoratou, Evropi; Elliott, Paul; Denny, Joshua C.; Malik, Rainer; Evangelou, Evangelos; Dehghan, Abbas; Dichgans, Martin; Tzoulaki, Ioanna (Circulation, 2019-07-23)
      Background: Drug effects can be investigated through natural variation in the genes for their protein targets. The present study aimed to use this approach to explore the potential side effects and repurposing potential ...
    • Why has positive inotropy failed in chronic heart failure? Lessons from prior inotrope trials 
      Ahmad, Tariq; Miller, P. Elliott; McCullough, Megan; Desai, Nihar R.; Riello, Ralph; Psotka, Mitchell; Boehm, Michael; Allen, Larry A.; Teerlink, John R.; Rosano, Giuseppe M. C.; Lindenfeld, JoAnn (European Journal of Heart Failur, 2019-09)
      Current pharmacological therapies for heart failure with reduced ejection fraction are largely either repurposed anti-hypertensives that blunt overactivation of the neurohormonal system or diuretics that decrease congestion. ...