|dc.description||Possible predictors of positive and negative affective response to oral d-Amphetamine were examined in healthy adults using secondary data analysis on two datasets. The predictors examined included subjective response to the drug, midbrain D2/D3 binding potential, and stable personality traits. Using correlational analyses, D2/D3 binding potential and stable personality traits were found to not have significant associations with positive or negative affect. In contrast, subjective response to d-amphetamine was found to be positively associated with negative affect, though this finding did not replicate across datasets. In subsequent multiple regression models, one dataset showed a significant positive relationship between negative affect and the degree to which participants subjectively felt the effects of the drug, while the other dataset showed a significant positive relationship between negative affect and the degree to which participants subjectively disliked the effects of the drug. Though the lack of replication across datasets makes it difficult to draw definitive conclusions, these findings suggest that negative affect may play a major role in people’s experience of drug use.
PSY-4999: Honors Thesis, Amy Booth||en_US