• About
    • Login
    View Item 
    •   Institutional Repository Home
    • Electronic Theses and Dissertations
    • Electronic Theses and Dissertations
    • View Item
    •   Institutional Repository Home
    • Electronic Theses and Dissertations
    • Electronic Theses and Dissertations
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of Institutional RepositoryCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsDepartmentThis CollectionBy Issue DateAuthorsTitlesSubjectsDepartment

    My Account

    LoginRegister

    Functional Characterization of an AMPA receptor auxiliary subunit GSG1L in vivo

    Kamalova, Aichurok
    0000-0002-5865-7115
    : http://hdl.handle.net/1803/16364
    : 2020-11-03

    Abstract

    AMPA receptors (AMPAR) are key mediators of fast excitatory neurotransmission within the brain. The functional identity of AMPAR at the synapses strongly contributes to molecular mechanisms of learning and memory. At the synapse, AMPARs are bound to their auxiliary subunits, which have a profound effect on AMPAR biogenesis. GSG1L is a recently identified auxiliary subunit that has a strong AMPAR regulatory function, unlike any known auxiliary subunit. The work presented in this dissertation aimed to determine the postsynaptic function of GSG1L. We report that AMPA receptor auxiliary subunit GSG1L controls short-term plasticity in anterior thalamic synapses that receive inputs from the cortex, but not in those receiving inputs from other pathways. A canonical auxiliary subunit stargazin co-exists in these neurons but is functionally absent from corticothalamic synapses. In GSG1L knockout mice, anterior thalamic neurons exhibit hyperexcitability and the animals have increased susceptibility to seizures, consistent with a negative regulatory role of GSG1L. We hypothesize that negative regulation of synaptic function by GSG1L plays a critical role in maintaining optimal excitation in the anterior thalamus.
    Show full item record

    Files in this item

    Icon
    Name:
    KAMALOVA-DISSERTATION-2020.pdf
    Size:
    4.238Mb
    Format:
    PDF
    View/Open
    Name:
    AK_thesis.docx
    Size:
    11.33Mb
    Format:
    Microsoft Word 2007
    View/Open

    This item appears in the following collection(s):

    • Electronic Theses and Dissertations

    Connect with Vanderbilt Libraries

    Your Vanderbilt

    • Alumni
    • Current Students
    • Faculty & Staff
    • International Students
    • Media
    • Parents & Family
    • Prospective Students
    • Researchers
    • Sports Fans
    • Visitors & Neighbors

    Support the Jean and Alexander Heard Libraries

    Support the Library...Give Now

    Gifts to the Libraries support the learning and research needs of the entire Vanderbilt community. Learn more about giving to the Libraries.

    Become a Friend of the Libraries

    Quick Links

    • Hours
    • About
    • Employment
    • Staff Directory
    • Accessibility Services
    • Contact
    • Vanderbilt Home
    • Privacy Policy