Search
Now showing items 1-10 of 27
Energetic costs regulated by cell mechanics and confinement are predictive of migration path during decision-making
(Nature Communications, 2019-09-13)
Cell migration during the invasion-metastasis cascade requires cancer cells to navigate a spatially complex microenvironment that presents directional choices to migrating cells. Here, we investigate cellular energetics ...
Non-contrast power Doppler ultrasound imaging for early assessment of trans-arterial chemoembolization of liver tumors
(Scientific Reports, 2019-09-10)
Trans-arterial chemoembolization (TACE) is an important yet variably effective treatment for management of hepatic malignancies. Lack of response can be in part due to inability to assess treatment adequacy in real-time. ...
Non-contrast power Doppler ultrasound imaging for early assessment of trans-arterial chemoembolization of liver tumors
(Scientific Reports, 2019-09-10)
Trans-arterial chemoembolization (TACE) is an important yet variably effective treatment for management of hepatic malignancies. Lack of response can be in part due to inability to assess treatment adequacy in real-time. ...
Experimentally-driven mathematical modeling to improve combination targeted and cytotoxic therapy for HER2+breast cancer
(Scientific Reports, 2019-09-06)
The goal of this study is to experimentally and computationally investigate combination trastuzumab-paclitaxel therapies and identify potential synergistic effects due to sequencing of the therapies with in vitro imaging ...
Biomineralization by particle attachment in early animals
(Proceedings of the National Academy of Sciences of the United States of America, 2019-09-03)
Crystallization by particle attachment (CPA) of amorphous precursors has been demonstrated in modern biomineralized skeletons across a broad phylogenetic range of animals. Precisely the same precursors, hydrated (ACC-H2O) ...
Racial/ethnic, age and sex disparities in leukemia survival among adults in the United States during 1973-2014 period
(PLoS One, 2019-08-19)
There has been marked improvement in leukemia survival, particularly among children in recent time. However, the long-term trends in survival among adult leukemia patients and the associated sex and racial survival disparities ...
Data on the negative regulation of invadopodia activity by MLCK
(Data in Brief, 2019-06)
Actomyosin contractility can promote extracellular matrix (ECM) degradation by invadopodia in cancer cells. However, we previously found that inhibiting myosin light chain kinase (MLCK) with siRNA did not change force ...
Evaluation of Synthetic Cytochrome P-450-Mimetic Metalloporphyrins To Facilitate "Biomimetic" Biotransformation of a Series of mGlu(5) Allosteric Ligands
(ACS Omega, 2019-07)
Allosteric ligands within a given chemotype can have the propensity to display a wide range of pharmacology, as well as unexpected changes in GPCR subtype selectivity, typically mediated by single-atom modifications to the ...
Synbiotics suppress colitis-induced tumorigenesis in a colon-specific cancer mouse model
(Plos One, 2019-06-26)
Although synbiotics may be effective in maintaining remission of inflammatory bowel disease, their anticarcinogenic effects are still debated. To address this issue, we evaluated the effects of synbiotics, probiotics, and ...
Towards A Microbead Occlusion Model of Glaucoma for a Non-Human Primate
(2019-08-09)
Glaucoma is a group of optic neuropathies associated with aging and sensitivity to intraocular pressure (IOP). The disease causes vision loss through the degeneration of retinal ganglion cell neurons and their axons in the ...