Browsing by Author "P. Jeffrey Conn"
Now showing items 1-16 of 16
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Yin, Shen (2013-12-16)Department: PharmacologyMetabotropic glutamate receptors (mGlus) are a group of Family C Seven Transmembrane Spanning Receptors that play important roles in modulating signaling transduction, particularly within the central nervous system. mGlu4 ...
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Misra, Sunita N (2008-07-17)Department: PharmacologyInvestigating genetic forms of epilepsy allows for improved understanding of epilepsy pathophysiology in general. Mutations in voltage-gated sodium channels are a frequent cause of genetic forms of epilepsy. First we ...
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Garcia, Bonnie Gale (2010-03-31)Department: PharmacologyStriatal medium spiny neurons (MSNs) receive glutamatergic afferents from the cerebral cortex that synapse onto the spine head and dopaminergic inputs from the substantia nigra which synapse onto the necks of dendritic ...
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Wenthur, Cody James (2015-07-15)Department: PharmacologyThe essential roles of glutamatergic signaling in both normal and impaired cognitive functioning have caused metabotropic glutamate (mGlu) receptors to become targets of interest for the treatment of psychiatric disorders. ...
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Grannan, Michael David (2016-11-21)Department: PharmacologyCurrent antipsychotic medications (APDs) for schizophrenia primarily treat positive symptoms (hallucinations, delusions) yet are largely ineffective in treating the negative (anhedonia, social withdrawal, apathy) and ...
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Bazalakova, Mihaela Hristova (2008-04-15)Department: NeuroscienceNeuroscience Dissertation under the direction of Professor Randy D. Blakely This dissertation is focused on the function and regulation of the choline transporter (CHT). I used CHT heterozygous and homozygous mice, and ...
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Betke, Katherine Michelle (2014-07-16)Department: PharmacologySynaptic transmission is characterized by exocytotic events which mediate the release of chemical transmitters to facilitate neuronal communication. Inhibitory presynaptic GPCRs act as feedback regulators limiting transmitter ...
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Shirey-Rice, Jana Kristin (2010-04-15)Department: PharmacologyMuscarinic acetylcholine receptors (mAChRs), specifically M1 and M4 subtypes, provide viable targets for the treatment of multiple central nervous system disorders. However, highly selective activators of either M1 or M4 ...
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Johnson, Kari Anne (2013-04-15)Department: PharmacologyMetabotropic glutamate receptors (mGluRs) are G protein-coupled receptors that play important roles in the modulation of neurotransmission in the central nervous system (CNS). The eight subtypes of mGluRs are differentially ...
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Young, Summer Elizabeth (2013-12-03)Department: PharmacologyThe platelet thrombin receptors Protease-activated receptor 1 (PAR1) and Protease activated receptor 4 (PAR4) stand at the intersection of coagulation and platelet activation. Thrombin receptors are thus excellent ...
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Xu, Ming (2006-04-04)Department: PharmacologyADAR2-mediated adenosine-to-inosine (A-to-I) RNA editing can affect the coding potential, splicing pattern, stability, and localization of the targeted RNA transcripts. ADAR2 contains two double-stranded RNA binding motifs ...
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Moran, Sean p (2019-12-03)Department: NeuroscienceMuscarinic acetylcholine receptors (mAChR) play important roles in regulating complex behaviors such as cognition, movement, and reward, making them ideally situated as potential drug targets for the treatment of several ...
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Le, Uyen Mai (2011-12-15)Department: Chemical and Physical BiologyAcetycholine is one of the major neurotransmitters that regulate various functions ranging from cognition to motor. It activates muscarinic acetylcholine receptors (mAChRs), which are highly expressed in the brain. mAChRs ...
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Aldrich, Leslie Nichole (2012-07-23)Department: ChemistryProgress toward the total synthesis of marineosins A and B, prodigiosin-like alkaloids with novel spiroiminal centers, is described. The synthesis of the proposed biosynthetic precursor was completed and the viability of ...
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Gosnell, Heather Brown (2011-04-15)Department: Molecular Physiology and BiophysicsMetabotropic glutamate receptors (mGluRs) are important modulators of excitatory transmission throughout the central nervous system, and have been implicated in a variety of neurological disorders. This work focuses ...
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Klar, Rebecca (2015-08-11)Department: PharmacologyOf the eight metabotropic glutamate (mGlu) receptor subtypes, only metabotropic glutamate receptor 7 (mGlu7) is expressed presynaptically at the Schaffer Collateral (SC)-CA1 synapse in the hippocampus in adult animals. ...