Browsing by Department "Molecular Physiology and Biophysics"
Now showing items 21-40 of 101
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(2016-03-11)Department: Molecular Physiology and BiophysicsEvidence suggests that chromatin-modifying complexes contribute to the uncontrolled cell proliferation of cancer cells through dysregulation of the epigenome. Histone deacetylases (HDACs) are a type of chromatin modifying ...
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(2006-04-06)Department: Molecular Physiology and BiophysicsThe protein complex composed of the cytoplasmic domain of band 3 (cdb3) and ankyrin forms one of the two major contact sites between the spectrin-based membrane skeleton and the lipid bilayer in human erythrocytes. This ...
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(2010-08-02)Department: Molecular Physiology and BiophysicsSirtuin 1 (Sirt1) is a NAD+-dependent deacetylase that exerts many of the pleiotropic effects of oxidative metabolism. Due to local hypoxia and hypertonicity, the renal medulla is subject to extreme oxidative stress. Here, ...
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(2015-10-20)Department: Molecular Physiology and BiophysicsAnalysis of MafB-/- mice suggested that this transcription factor was essential to islet α- and β-cell formation during development, although the postnatal physiological impact could not be studied because these mutants ...
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(2016-10-03)Department: Molecular Physiology and BiophysicsMOLECULAR PHYSIOLOGY & BIOPHYSICS Exploring the Function of G6PC2 in Pancreatic Islet Beta Cells Kayla Boortz Dissertation under the direction of Professor Richard O’Brien, Ph.D. G6PC2 encodes an islet-specific ...
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(2017-08-02)Department: Molecular Physiology and BiophysicsType 2 diabetes (T2D) is characterized by hyperglycemia, which arises due to insulin resistance and beta cell failure and/or decreased beta cell mass. Genome-wide association studies have shown that single nucleotide ...
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(2012-01-25)Department: Molecular Physiology and BiophysicsThis project and the experiments discussed in this document sought to contribute a functional basis for SNPs within G6PC2 significantly associated with variations in fasting blood glucose by genome-wide association study. ...
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(2019-02-18)Department: Molecular Physiology and BiophysicsEpidemiological studies have demonstrated an inverse correlation between high-density lipoproteins (HDL) cholesterol and cardiovascular disease (CVD) risk; however therapeutic approaches aimed at raising HDL cholesterol ...
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(2005-03-09)Department: Molecular Physiology and BiophysicsAutism is a severe neurodevelopmental disorder characterized by deficits in language and social interaction, and patterns of repetitive and stereotyped behaviors, interests and activities. Evidence indicates that autism ...
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(2015-11-19)Department: Molecular Physiology and BiophysicsThe heart must function properly to perform its essential role in supplying the body with the oxygen and nutrients required for survival. Over the course of a lifetime the heart will eventually be exposed to conditions of ...
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(2015-10-20)Department: Molecular Physiology and BiophysicsDiabetes is characterized by excess levels of glucose and lipid in the blood, which have been proposed to directly and negatively impact islet β cells, exacerbating symptoms and promoting disease progression. Our understanding ...
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(2017-08-26)Department: Molecular Physiology and BiophysicsHaploinsufficiency of the melanocortin-4 receptor (MC4R) is the most common monogenetic obesity syndrome in humans. This syndrome is associated with a reduction in autonomic tone, bradycardia, hyperinsulinemia and a reduced ...
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(2008-08-04)Department: Molecular Physiology and BiophysicsBone morphogenetic protein 4 (Bmp4) is a multi-functional, developmentally regulated gene and is essential for early mouse development. Little is known about the transcriptional regulation of Bmp4. To investigate the ...
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(2017-02-08)Department: Molecular Physiology and BiophysicsCaveolin-1 (CAV1) is an essential protein for the formation of caveolae, invaginations found at the plasma membrane. Caveolae are abundant in many cell types and numerous functions have been identified, including modulating ...
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(2011-08-24)Department: Molecular Physiology and BiophysicsThe goal of this dissertation was to elucidate the metabolic and hepatocellular consequences associated with chronic consumption of a high-fat, high-fructose diet (HFFD), focusing on perturbations in the regulation of HGU ...
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(2009-08-04)Department: Molecular Physiology and BiophysicsAdenoviruses (Ads) are a promising tool for gene and vaccine delivery. Though known for over 50 years, details about Ad structure and intermediates of its lifecycle remain elusive. CryoEM, a technique suitable for studying ...
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(2017-08-09)Department: Molecular Physiology and BiophysicsThe two-pore domain K<sup>+</sup> (K2P) channel TALK-1 is highly expressed in the pancreatic islet and is linked to type 2 diabetes mellitus (T2DM) risk through a non-synonymous polymorphism (rs1535500). Here, we established ...
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(2019-04-17)Department: Molecular Physiology and BiophysicsThe current obesity public health crisis is linked directly with liver health through a parallel epidemic of non-alcoholic fatty liver disease (NAFLD). NAFLD has direct effects on liver health while acting as an independent ...
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(2015-03-25)Department: Molecular Physiology and BiophysicsThe prevalence of type 2 diabetes has increased dramatically in parallel with excess caloric intake and sedentary lifestyles. Insulin resistance precedes the development of type 2 diabetes. The liver is a major insulin-responsive ...
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(2015-01-07)Department: Molecular Physiology and BiophysicsInappropriate glucagon secretion contributes to hyperglycemia in inflammatory disease. Previous work implicates the pro-inflammatory cytokine, interleukin-6 (IL-6), in glucagon secretion. IL-6 knock-out mice have a blunted ...