Browsing by Title
Now showing items 1560-1579 of 17382
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(2020-03-31)Department: OtherPrevious literature has examined the effect of acoustic bandwidth on bimodal benefit for speech recognition (e.g., Zhang et al., 2010; Sheffield & Gifford, 2014). The current study extends this earlier work to examine the ...
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(Vanderbilt University, 2013-04-17)
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(2016-07-29)Department: Hearing and Speech SciencesInteraural time (ITD) and level differences (ILD) are susceptible to distortion by multipath acoustics due to reverberation, echoes, and potentially with open-fit, behind-the-ear (BTE) hearing aids, which pose an additional ...
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(2022-02-02)Department: Molecular Pathology & ImmunologyCancer resequencing studies have revealed epigenetic enzymes as common targets for recurrent mutations. The monomethyltransferase MLL3 is among the most recurrently mutated enzymes in ER+ breast cancer. The H3K4me1 marks ...
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(2016-11-16)Department: PsychologyData presented in this paper address questions about binge eating disorder (BED) recognition as a barrier to care, attitudes toward binge eating treatment options, and feasibility of guided self-help (GSH) cognitive ...
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(2010-06-01)Department: ChemistryAs the field of chemical biology evolves, so does the development of novel bioanalytical techniques capable of accurately measuring biochemical composition and regulation. This dissertation explores three aspects of ...
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(2014-07-28)Department: Medicine, Health, and SocietyThe goal of this project is to re-evaluate patient awareness of Vanderbilt’s biobanking practices and whether patients are interested in having more information of the project. 61 exit-interviews were conducted with adult ...
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(2015-12-08)Department: NeuroscienceAutism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterized by deficits in social behavior. It is unclear if deficits are due to disinterest in social stimuli, or to an elevated stress response. The ...
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(2010-12-13)Department: Molecular Physiology and BiophysicsThe goal of my dissertation project was to characterize interactions between the transactivator Rap1 and Taf subunits of the TFIID complex. This experimental problem falls under a larger umbrella of gene regulation, since ...
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(2010-10-29)Department: BiochemistryThe mechanism controlling the switch between gene activation and repression is critically important for understanding the process of transcriptional regulation. Gene expression is highly controlled through a dynamic exchange ...
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(2012-03-28)Department: BiochemistrySimian Virus 40 uses its Large T antigen protein to bind and inactivate retinoblastoma tumor suppressor proteins, yielding cell transformation. T antigen is a modular protein with four domains connected by linkers. The ...
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(2008-07-28)Department: BiochemistryThe replication of DNA occurs through a complex series of steps involving the coordinated action of many proteins. DNA polymerase alpha/primase (pol-prim) is a critical DNA replication factor that synthesizes short RNA-DNA ...
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(2015-01-16)Department: PharmacologyPhospholipase D (PLD) is a ubiquitous enzyme found in prokaryotic and eukaryotic organisms that generates phosphatidic acid. A number of human bacterial pathogens produce PLD as virulence factors to promote infections. ...
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(2019-03-25)Department: Chemical and Physical BiologyCells constantly sense and respond to cues via signaling networks. These networks operate in dynamic systems and often serve multiple purposes, translating multiple inputs into multiple outputs depending on context. Because ...
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(2021-06-16)Department: Biological SciencesDNA damage within a cell can cause genome instability if not properly corrected. Endogenous factors including reactive metabolites and oxidative stress cause DNA damage in the form of modified DNA nucleobases. Base excision ...
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(2010-05-21)Department: Chemical EngineeringInfection is a common complication in open fractures that compromises bone healing. Currently, the clinical standard care for treating contaminated open fractures comprises a staged approach, wherein the wound is first ...
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(University of Colorado Law Review, 1995)This article offers an early examination of the law and governance of biodiversity (circa 1995) through the lenses of the Endangered Species Act, Clean Water Act, and Coastal Zone Management. It suggests that true multi-scalar, ...
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(2012-12-03)Department: Biomedical EngineeringMacrophages have been proposed as a potential therapeutic target because of their central role in the progression of a number of debilitating diseases, such as cancer and cardiovascular diseases. However, macrophages are ...
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(2014-07-02)Department: Biological SciencesMany eukaryotes use the ribonucleoprotein telomerase to replenish telomeric sequences lost during conventional DNA replication. In Saccharomyces cerevisiae, telomerase contains the catalytic reverse transcriptase, Est2p, ...
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(Wiley & Putnam, 1846)